In several short years, the Lower East Side has gone from a garment district to an underground hotspot to an actual hotspot and now, basically, to shit. On weekends, the streets are so crowded, it feels like Times Square. The bar-to-litter ratio is one to one. And the fashion, once so inspirational, has melted into the madness of rehab jeans and rehashed trends. Aside from occasional glimmers at Annex and Foley + Corinna, the whole place has gone stale. But Karl Lagerfeld still uses Rivington and Delancey as his default spot for impromptu photo shoots at 3 am, and Gemma Ward's announced it as her new haunt in Paris Vogue. Then last week, we got an email from designer Sam Shipley, saying he was scouting a new apartment near Pixie Mart. And today? Charlotte Ronson debuted her new campaign in WWD, starring Annabelle Dexter Jones and Donald Cumming, the lead singer of The Virgins. Last season's shots were done in Central Park, but this season the images come from The Lower East Side, not far from Charlotte's Mulberry St. store. Which leads to the question: Is the neighborhood getting another shot of trend infusions, or has it just finally hit the mainstream?